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pentobarbital will minimize the extent or outcome of etravirine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can reduce panobinostat amounts by ~70% and lead to